C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/02 (2006.01) A61K 31/438 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) C07D 211/96 (2006.01) C07D 405/00 (2006.01)
Patent
CA 2569507
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
L'invention concerne des inhibiteurs du type 1 de la 11-ß hydroxyl stéroïde déshydrogénase, des antagonistes du récepteur minéralocorticoïde (MR) et des compositions pharmaceutiques de ceux-ci. Les composés selon l'invention peuvent être utiles dans le traitement de diverses maladies associées à l'expression ou à l'activité du type 1 de la 11-ß hydroxyl stéroïde déshydrogénase et/ou des maladies associées à un excès d'aldostérone.
Li Yun-Long
Metcalf Brian W.
Xu Meizhong
Yao Wenqing
Zhang Colin
Incyte Corporation
Smart & Biggar
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