Amido compounds and their use as pharmaceuticals

Details Amido compounds and their use as pharmaceuticals Amido compounds and their use as pharmaceuticals

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/445 (2006.01) A61P 3/00 (2006.01) C07D 211/56 (2006.01) C07D 401/14 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01)

Patent

CA 2621255

The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

L'invention concerne des inhibiteurs de la 11-ß hydroxyl steroïde déshydrogénase de type 1, des antagonistes du récepteur de minéralocorticoïde (MR), et des compositions pharmaceutiques contenant ces composés. Les composés de l'invention conviennent pour le traitement de diverses pathologies associées à l'expression ou à l'activité de 11-ß hydroxyl stéroide déshydrogénase de type 1 et ou de maladies associées à un excès d'aldostérone.

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