(amido)-n-substituted bleomycins, salts thereof and process...

Details (amido)-n-substituted bleomycins, salts thereof and process... (amido)-n-substituted bleomycins, salts thereof and process...

C - Chemistry, Metallurgy

07

K

530/9

C07K 9/00 (2006.01)

Patent

CA 1246057

ABSTRACT OF THE DISCLOSURE A promising carcinostatic (amido)N-substituted bleomycin represented by the following formula, or a salt thereof and a process for the preparation thereof: Image (I) wherein BM represents a moiety of bleomycin skeleton; X represents an alkyl of 1 to 18 carbon atoms, an amino- alkyl of 1 to 12 carbon atoms, a lower alkyl having a halogen, phenyl indolyl, 5- or 6-membered heterocyclic group, or (lower)alkylamino (the alkyl group may have a substituent group) as a substituent, naphthyl, thiazolyl, or N-phenyl(lower)alkylpiperazinyl; and R represents a terminal amino residue of the bleomycin.

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