Amidomethyl substituted...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/06 (2006.01) A61K 38/05 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2539895

Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R1, R2 , R3 and R4 have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

La présente invention concerne de nouveaux composés présentant une activité d'inhibition d'endopeptidase neutre (NEP) et/ou d'endopeptidase soluble humaine (hSEP), de formule générale (I), où les substituants R?1¿, R?2¿, R?3¿ et R?4¿ ont les significations données dans la description, ainsi que des médicaments contenant ces composés, notamment des médicaments conçus pour traiter ou prévenir des maladies cardiovasculaires, des dysfonctionnements sexuels et/ou des états pathologiques associés à une apoptose.

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