Amidophosphinephosphinite compounds

Details Amidophosphinephosphinite compounds Amidophosphinephosphinite compounds

C - Chemistry, Metallurgy

07

F

C07F 9/46 (2006.01) B01J 31/18 (2006.01) C07B 53/00 (2006.01) C07C 67/283 (2006.01) C07C 68/06 (2006.01) C07C 69/145 (2006.01) C07C 69/614 (2006.01) C07C 69/78 (2006.01) C07C 69/96 (2006.01) C07C 269/06 (2006.01) C07C 271/32 (2006.01) C07D 215/14 (2006.01) C07F 9/655 (2006.01) C07F 9/6568 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2230770

Novel chiral amidophosphine-phosphinite compounds, which are present in (R) and (S) form, of the general formula (see formula I) wherein R1 signifies alkyl, cycloalkyl or aralkyl, R2 signifies alkyl, cycloalkyl, aralkyl or aryl and R3 and R4 each independently signify alkyl, cycloalkyl, aralkyl, aryl or heteroaryl or R3 and R4 together with the respective phosphorus atom signify a 9-dibenzophospholyl, 9-phosphabicyclo- [3.3.1]nonyl or 9-phosphabicyclo[4.2.1]nonyl group and * denotes a chiral centre, are manufactured by reacting a compound of the general formula R1C(OH)-CONHR2 (III) with a disubstituted chlorophosphane of the general formula R3R4PCl (IV) in a solvent and in the presence of a base. As ligands the amidophosphine-phosphinite compounds in accordance with the invention form complexes with Group VIII transition metals, especially with rhodium, iridium, ruthenium and palladium, and optionally with further ligands, and such complexes are likewise an object of the present invention; they can be used as catalysts for enantioselective reactions, especially for asymmetric hydrogenations, enantioselective hydrogen displacements and allylic substitution reactions.

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