Aminatetralone derivatives and process for producing the same

Details Aminatetralone derivatives and process for producing the same Aminatetralone derivatives and process for producing the same

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 209/68 (2006.01) C07C 211/60 (2006.01) C07C 213/08 (2006.01) C07C 217/74 (2006.01) C07C 233/15 (2006.01) C07C 233/41 (2006.01) C07C 233/66 (2006.01) C07C 269/06 (2006.01) C07C 271/24 (2006.01) C07C 271/28 (2006.01) C07C 303/40 (2006.01) C07C 311/08 (2006.01) C07C 311/09 (2006.01) C07C 311/21 (2006.01) C07D 405/14 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2213201

A process for producing a compound (4) according to the above reaction scheme (I), whereby aminotetralone derivatives useful as an intermediate for industrially producing camptothecin derivatives can be obtained readily in high yields, wherein R1 and R2 represent each H, halogeno, OH or C1-C6 alkyl; X and Y represent each a protected amino group; and n is 0 to 4.

Procédé de fabrication d'un composé (4) au moyen de la suite de réactions (I) décrite ci-dessus, permettant d'obtenir facilement avec un fort rendement des dérivés d'aminotétralone servant d'intermédiaire pour la production industrielle de dérivés de camptothécine où R?1¿ et R?2¿ représentent chacun H, halogène, OH ou un alkyl C¿1?-C¿6?; X et Y représentent chacun un groupe amino protégé et n vaut de 0 à 4.

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