C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/84 (2006.01) A61K 31/165 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2467798
Disclosed are compounds of formula (1): and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein Rn, Rc, R1, n and R20 are defined herein. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
L'invention concerne des composés de formule générale (I) ainsi que des sels et des esters pharmaceutiquement acceptables de ceux-ci, utiles dans le traitement et la prévention de la maladie d'Alzheimer et d'autres maladies identiques, dans laquelle R¿n?, R¿c?, R¿1?, n et R¿20? ont la signification indiquée dans la description. Ces composés comprennent des inhibiteurs de l'enzyme bêta-sécrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par un dépôt du peptide bêta-amyloïde chez un mammifère. Lesdits composés de l'invention sont utiles dans des compositions pharmaceutiques et des méthodes de traitement destinées à réduire la formation du peptide bêta-amyloïde.
Roels Christina M.
Romero Arthur Glenn
Schostarez Heinrich
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
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