Amine base salts of saha and polymorphs thereof

Details Amine base salts of saha and polymorphs thereof Amine base salts of saha and polymorphs thereof

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/167 (2006.01) A61K 31/198 (2006.01) A61P 35/00 (2006.01) C07C 229/26 (2006.01)

Patent

CA 2663614

The present invention provides amine base salts of SAHA, polymorphs and pharmaceutical compositions thereof. The invention provides a method of treating cancer by administering the pharmaceutical composition. The invention also provides a crystalline composition comprising the amine base and SAHA. The invention also provides methods of obtaining the amine base salt and crystalline composition.

La présente invention concerne des sels aminés de SAHA, des formes polymorphes et des compositions pharmaceutiques de ceux-ci. L'invention concerne également un procédé de traitement du cancer par l'administration de la composition pharmaceutique. L'invention concerne en outre une composition cristalline comportant la base aminée et de l'acide suberoylaniline-hydroxymique. L'invention concerne enfin des procédés d'obtention du sel aminé et de la composition cristalline.

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