Amine compound and pharmaceutical use thereof

Details Amine compound and pharmaceutical use thereof Amine compound and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

C

C07C 217/64 (2006.01) A61K 31/137 (2006.01) A61K 31/165 (2006.01) A61K 31/343 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/4453 (2006.01) A61K 31/5375 (2006.01) A61K 31/661 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 41/00 (2006.01) A61P 43/00 (2006.01) C07C 255/54 (2006.01) C07C 255/59 (2006.01) C07C 317/22 (2006.01) C07C 323/19 (2006.01) C07C 323/32 (2006.01) C07D 211/14 (2006.01) C07D 295/08 (2006.01) C07D 307/79 (2006.01) C07D 317/22 (2006.01) C07D 317/62 (2006.01) C07D 333/

Patent

CA 2690686

It is intended to provide a novel amine compound represented by the following general formula (I), a pharmaceutically acceptable acid addition salt thereof, a hydrate thereof or a solvate thereof, which has an excellent peripheral blood lymphocyte decreasing action, exhibits excellent immunosuppressive action, antirejection action and the like, and has reduced side effects such as bradycardia. (In the formula, each symbol has the same meaning as in the description.)

La présente invention concerne un nouveau composé aminé représenté par la formule générale suivante (I), un sel d'addition d'acide de celui-ci, un hydrate de celui-ci ou un solvate de celui-ci pharmaceutiquement acceptables, qui agit de manière excellente pour diminuer les lymphocytes du sang périphérique, présente une action immunosuppressive, une action anti-rejet et équivalents excellentes, et a permis de réduire les effets secondaires tels que la bradycardie. (I) (Dans la formule, chaque symbole a la même signification que dans la description).

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