Amine compounds, their production and use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 221/02 (2006.01) A61K 31/395 (2006.01) C07C 233/40 (2006.01) C07C 235/34 (2006.01) C07C 235/84 (2006.01) C07C 311/18 (2006.01) C07D 209/96 (2006.01) C07D 211/14 (2006.01) C07D 211/22 (2006.01) C07D 211/34 (2006.01) C07D 213/38 (2006.01) C07D 221/10 (2006.01) C07D 221/20 (2006.01) C07D 223/14 (2006.01) C07D 223/16 (2006.01) C07D 241/38 (2006.01) C07D 265/34 (2006.01) C07D 295/125 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01) C07D

Patent

CA 2163325

A compound of the formula: Image (I) wherein Ar1 and Ar2 independently present an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydro-carbon group having at least 2 carbon atoms and optionally having ether oxygen or sulfur in the carbon chain; R1 and R3 independently represent -CO-R, -CONH-R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R2 and R4 independently represent hydrogen or an alkyl group; R2 and R4 independently represent hydrogen or an alkyl group; R1 and R2 or R3 and R4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof have excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.

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