Amine derivative having npy y5 receptor antagonist activity...

A - Human Necessities – 61 – K

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A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/538 (2006.01) A61K 31/553 (2006.01) A61P 3/04 (2006.01) A61P 43/00 (2006.01) C07D 211/14 (2006.01) C07D 213/74

Patent

CA 2703797

This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I): formula (I): (see formula I) a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted lower alkyl, Y is -S(O)n- wherein n is 1 or 2, or -CO-, R2 is hydrogen or lower alkyl, R7 is hydrogen or lower alkyl, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.

L'invention porte sur un coupe-faim ou agent anti-obésité contenant un composé représenté par la formule (I) ci-après, un sel pharmaceutiquement acceptable de celui-ci ou un solvate de n'importe lequel d'entre eux. (Dans la formule, R1 représente un alkyle inférieur facultativement substitué; Y représente -S(O)n- (où n est 1 ou 2) ou -CO-; R2 représente un hydrogène ou un alkyle inférieur; R7 représente un hydrogène ou un alkyle inférieur; X représente un alkylène inférieur, un alcénylène inférieur, un arylène, un cycloalkylène ou similaires; et Z représente un alkyle inférieur, un groupe hydrocarboné cyclique facultativement substitué, un groupe hétérocyclique facultativement substitué ou similaires).

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