C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 231/38 (2006.01) C07D 249/14 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2548156
Compounds of formula (I), wherein R1, R2, R3, R4, R5, B and X have the meanings cited in Claim 1, are inhibitors of tyrosinkinases, particularly TIE- 2, and Raf kinases and can be used inter alia in the treatment of tumors.
La présente invention concerne des composés de formule (I) dans laquelle R?1¿, R?2¿ , R?3¿ , R?4¿ , R?5¿, B et X ont les correspondances indiquées dans la revendication 1. Ces composés sont des inhibiteurs des tyrosine kinases, en particulier TIE-2, et des Raf-kinase, et peuvent être utilisés entre autres pour traiter des tumeurs.
Hoelzemann Guenter
Rautenberg Wilfried
Schiemann Kai
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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