Amine derivatives for the treatment of apoptosis

Details Amine derivatives for the treatment of apoptosis Amine derivatives for the treatment of apoptosis

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61P 43/00 (2006.01) C07C 233/00 (2006.01) C07C 235/00 (2006.01) C07C 237/22 (2006.01) C07D 207/16 (2006.01) C07D 217/26 (2006.01) C07D 277/06 (2006.01)

Patent

CA 2397651

The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.

La présente invention concerne des dérivés d'amine substitués, utiles notamment en tant que composés actifs sur le plan pharmaceutique, ainsi que des formulations pharmaceutiques contenant ces dérivés d'amine de formule I. Lesdits dérivés d'amine substitués se révèlent être d'efficaces modulateurs, plus particulièrement des inhibiteurs, de la fonction et/ou de l'activation de Bax. Cette invention concerne également de nouveaux dérivés d'amine substitués ainsi que des méthodes permettant leur préparation.

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