Amine derivatives, processes for producing same, and use...

Details Amine derivatives, processes for producing same, and use... Amine derivatives, processes for producing same, and use...

C - Chemistry, Metallurgy

07

C

C07C 311/08 (2006.01) A61K 31/135 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 211/53 (2006.01) C07C 217/20 (2006.01) C07C 217/60 (2006.01) C07C 217/84 (2006.01) C07C 233/25 (2006.01) C07C 233/43 (2006.01) C07C 255/54 (2006.01) C07D 207/325 (2006.01) C07D 207/335 (2006.01) C07D 213/42 (2006.01) C07D 217/04 (2006.01) C07D 217/16 (2006.01) C07D 233/64 (2006.01) C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 295/096 (2006.01) C07D 295/135 (2006.01) C07D 307/52 (2006.01) C07D

Patent

CA 2196672

A novel amine derivative represented by general formula (I) and a salt thereof, each being useful as an antiarrhythmic, wherein, for example, A represents -(CH2)-O-, -(CH2)2-O- or -(CH2)2-NH-; B represents -(CH2)2-; R1 represents hydrogen, halogen, nitro, 1-pyrrolyl, acetamido, amino or dimethylamino; R2 represents hydrogen or nitro; R3 and R4 represent each hydrogen; R8a and R8b both represent chloro or methoxy at the same time; R9 represents hydrogen or amino; R represents methyl; and X represents methanesulfonamido, 1-imidazolyl or nitro.

Nouveau dérivé amine représenté par la formule générale (I) et sel de ce dérivé, chacun étant utile comme antiarythmique; dans cette formule, par exemple A représente -(CH2)-O-, -(CH2)2-O- ou -(CH2)2-NH-; B représente -(CH2)2-; R1 représente hydrogène, halogène, nitro, 1-pyrrolyle, acétamido, amino ou diméthylamino; R2 représente hydrogène ou nitro; R3 et R4 représentent chacun hydrogène; R8a et R8b représentent l'un et l'autre et simultanément chloro ou méthoxy; R9 représente hydrogène ou un amino; R représente méthyl; et X représente méthanesulfonamido, 1-imidazolyle ou nitro.

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