Amine-derivatized nucleosides and oligonucleosides

Details Amine-derivatized nucleosides and oligonucleosides Amine-derivatized nucleosides and oligonucleosides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 19/04 (2006.01) C07K 2/00 (2006.01) C12N 9/96 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2170869

Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the alkylamino group.

L'invention concerne des nucléosides et des oligonucléosides modifiés par l'adjonction de fonctions alkylamino, ainsi que leurs dérivés. Dans certaines formes d'exécution, les composés de l'invention comportent en outre des stéroïdes, des molécules reporteurs, des enzymes reporteurs, des molécules lipophiles, des peptides ou des protéines, fixés aux nucléosides par le groupe alkylamino.

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