Amine linked modulators of .gamma.-secretase

Details Amine linked modulators of .gamma.-secretase Amine linked modulators of .gamma.-secretase

C - Chemistry, Metallurgy

07

C

C07C 229/34 (2006.01) A61K 31/195 (2006.01) A61K 31/404 (2006.01) A61K 31/435 (2006.01) A61P 25/28 (2006.01) C07C 229/42 (2006.01) C07C 255/58 (2006.01) C07D 209/08 (2006.01) C07D 213/74 (2006.01) C07D 215/06 (2006.01) C07D 215/38 (2006.01) C07D 217/04 (2006.01)

Patent

CA 2703636

The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with y-secretase activity, including Alzheimer's disease.

La présente invention concerne des composés de formule I tels que représentés ci-dessous, les définitions de A, X, Y, R1, R2, R3, R4, R5, R6, R7, R8, et R9 étant explicitées dans la spécification. Les composés de formule I sont utiles dans le traitement de maladies associées à l'activité de la g-secrétase, notamment la maladie d'Alzheimer.

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