C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/497 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07D 211/58 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2598460
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: Chemical formual should be inserted here as it appears on the abstract in paper form. and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed- type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
La présente invention a trait à un composé, ou enantiomères, stéréoisomères, rotamères, tautomères, racémates ou prodrogue dudit composé, ou des sels, solvates ou esters dudit composé, ou dudit prodrogue, ledit composé étant représenté par la formule générale (I), et les sels, solvates et esters de celui-ci pharmaceutiquement acceptables. L'invention a également trait à un procédé de traitement de maladies liés à la chimiokine, tel que, la thérapie palliative, la thérapie curative, la thérapie prophylactique de certaines maladies et conditions telles que des maladies inflammatoires (des exemples non limitatifs comprennent, le psoriasis), des maladies auto-immunes (des exemples non limitatifs comprennent le rejet de greffe allogénique, le rejet de xénogreffe) des maladies infectieuses (par exemple, la lèpre tuberculoïde), des éruptions médicamenteuses fixes, des réactions d'hypersensibilité retardées cutanées, l'inflammation ophtalmique, le diabète insulino-dépendant, la méningite virale et des tumeurs mettant en oeuvre un composé de formule (I).
Hobbs Douglas W.
Kozlowski Joseph A.
Mcguinness Brian F.
Rosenblum Stuart B.
Shao Yuefei
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pharmacopeia Inc.
Schering Corporation
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