Amine salts of an integrin receptor antagonist

Details Amine salts of an integrin receptor antagonist Amine salts of an integrin receptor antagonist

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2465416

Amine salts of 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)- propyl]imidazolidin-1-yl}-3-(6-methoxy-pyridin-3-yl)propionic acid are potent antagonists of the integrin .alpha.v.szlig.3 receptor and are useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salts as well as pharmaceutical compositions containing the salts and methods of using the salts.

L'invention concerne des sels aminés d'acide 3-{2-oxo-3-[3-(5,6,7,8-tétrahydro[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3-(6-méthoxy-pyridin-3-yl)propionique constituant des antagonistes puissants du récepteur de l'intégrine .alpha.v.beta.3, et s'avérant utiles pour la prévention et/ou le traitement de l'ostéoporose et de la resténose vasculaire, ainsi que des troubles associés à une angiogénèse excessive, notamment une dégénération maculaire, une rétinopathie diabétique, une athérosclérose, une arthrite inflammatoire, un cancer, et une croissance tumorale métastatique. L'invention concerne également un procédé de préparation de nouveaux sels et de compositions pharmaceutiques contenant ces sels et des procédés d'utilisation de ces sels.

Affiliated with

Also associated with

Rating

Amine salts of an integrin receptor antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amine salts of an integrin receptor antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amine salts of an integrin receptor antagonist will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1827784