C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61K 31/166 (2006.01) A61K 31/40 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/455 (2006.01) A61P 25/28 (2006.01) C07C 237/22 (2006.01) C07D 207/48 (2006.01) C07D 213/82 (2006.01) C07D 263/48 (2006.01)
Patent
CA 2453451
The present invention relates to compounds of formula (I) useful in treating Alzheiner's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheiner's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
La présente invention a trait à des composés de formule (I) utile dans le traitement de la maladies d'Alzheimer et d'autres maladies similaires. Lesdits composés comprennent des inhibiteurs de l'enzyme de la bêtasécrétase qui sont utiles dans le traitement de la maladies d'Alzheimer et d'autres maladies caractérisées par le dépôt du peptide A bêta chez un mammifère. Les composés de l'invention sont utiles dans des compositions pharmaceutiques et des procédés de traitement pour réduire la formation du peptide A bêta.
Chrusciel Robert Alan
Schostarez Heinrich Josef
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company Llc
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