Aminediols for the treatment of alzheimer's disease

Details Aminediols for the treatment of alzheimer's disease Aminediols for the treatment of alzheimer's disease

C - Chemistry, Metallurgy

07

D

C07D 277/52 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 25/28 (2006.01) C07C 215/28 (2006.01) C07C 233/69 (2006.01) C07C 235/84 (2006.01) C07C 255/44 (2006.01) C07C 323/42 (2006.01) C07D 213/40 (2006.01) C07D 263/48 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2450205

The present invention relates to compounds of formula useful in treating Alzheimer's disease and other similar disease. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Cette invention concerne des composés représentés par la formule (..) convenant pour le traitement de la maladie d'Alzheimer et autres pathologies analogues. Ces composés renferment des inhibiteurs de l'enzyme bêta sécrétase qui conviennent bien pour le traitement de la maladie d'Alzheimer et autres maladies caractérisées par des dépôts de peptides A bêta chez les mammifères. Les composés selon l'invention sont utiles pour des compositions pharmaceutiques et des méthodes de traitement visant à réduire la formation de peptides A bêta.

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