Amines

C - Chemistry – Metallurgy – 07 – C

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260/550.5, 260/5

C07C 13/00 (2006.01) C07D 277/34 (2006.01)

Patent

CA 1093095

ABSTRACT OF THE DISCLOSURE This invention relates to amines of the general formula Image R1 in 2 or 3 position is selected from the group consisting of -CH2CH=CH2, -OCH2CH=CH2, -OCH2C=CH, alkoxyalkyl, HOCH2CH2NHCOCH2O-, CH3OCH2CH2NHCOCH2O- and -CH=NOR, wherein R is selected from the group consisting of hydrogen or alkyl having 1 to 6 carbon atoms, R2 is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy, R5 is selected from the group con- sisting of hydrogen and alkyl, R9 is selected from the group consisting of hydrogen and carbamyl, Y is a divalent member selected from the group c??? sisting of -0-, and -CH2, n is an integer from 0 to 5, inclusive, m is an integer from 0 to 2, inclusive, and Ar is a phenyl nucleus, whereby R1 is bound in 2 or 3 position to the phenyl, whereby Y is CH2, n is a 1 - 5, or a therapeutically acceptable acid addition salt thereof. These compounds are prepared according to known methods. They are useful in treating cardio- vascular diseases by virtue of their ?-receptor activity.

238763

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