Amines

Details Amines Amines

C - Chemistry, Metallurgy

07

C

167/246, 260/290

C07C 211/26 (2006.01) A61K 31/135 (2006.01) A61K 31/185 (2006.01) A61K 31/33 (2006.01) C07C 211/27 (2006.01) C07C 211/29 (2006.01) C07C 211/30 (2006.01) C07C 211/49 (2006.01) C07C 215/46 (2006.01) C07C 215/50 (2006.01) C07C 217/54 (2006.01) C07C 217/58 (2006.01) C07C 309/14 (2006.01) C07C 309/24 (2006.01) C07C 335/32 (2006.01) C07D 209/04 (2006.01)

Patent

CA 2017966

H-399/405 CA ABSTRACT AMINES The invention concerns compounds having formula: Image (Ia) or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar1-A1-; Ar and Ar1 are the same or different aryl groups (including heteroaryl) which are optionally substituted, eg by one or more substituents commonly used in pharmaceutical chemistry; A and A1 are the same or different alkylene groups having one or two carbon atoms linking Ar or Ar1 to N and optionally substituted by lower alkyl and/or optionally substituted aryl, B is an alkylene group of 3 or 4 carbon atoms, which may be substituted by lower alkyl; D1 represents halogen, CH3, CR1R2NH2, SO3H or SO2NR6R7 where R1 and R2 are independently hydrogen or lower alkyl and R6 and R7 are each hydrogen, lower alkyl or aralkyl of 7 to 12 carbon atoms or R6 and R7 togehter with the nitrogen atom to which they are attached represent a 5 or 6 membered ring, which compounds are useful, for treating depression or cerebral insufficiency or dementias in animals.

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