C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/00 (2006.01) C07C 211/00 (2006.01) C07C 217/58 (2006.01) C07D 307/14 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2486055
One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson~s disease, spasticity. Tourette~s syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton~s headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn~s disease, malignant gliomas, neurodegenerative diseases, Huntington~s chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.
Selon un aspect, l'invention concerne des amines. Selon un autre aspect, l'invention concerne l'utilisation des amines comme inhibiteurs de transporteur d'anandamide de type mammalien. Les composés décrits sont également utiles pour le traitement d'un certain nombre de troubles, d'affections et de maladies dont souffrent les mammifères, y compris mais pas seulement: asthme, douleur neuropathique, douleur persistante, douleur inflammatoire, hyperactivité, hypertension, ischémie cérébrale, maladie de Parkinson, spasticité, syndrome de Gilles de la Tourette, schizophrénie, choc hémorragique, choc septique, choc cardiaque, migraine, céphalée vasculaire de Horton, sclérose en plaques, anorexie, syndrome cachectique, rejet d'organe, maladies auto-immunes, allergie, arthrite, maladie de Crohn, gliomes malins, maladies neurodégénératives, chorée de Huntington, glaucome, nausée, anxiété, psychose, hyperactivité avec déficit de l'attention, éjaculation précoce, et accident vasculaire cérébral. Selon un autre aspect, l'invention concerne des librairies combinatoires d'amines, et des procédés relatifs à leur élaboration.
Aquila Brian M.
Hopkins Seth
Lockshin Curtis A.
Wang Fengjiang
Borden Ladner Gervais Llp
Sepracor Inc.
Sunovion Pharmaceuticals Inc.
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