Amino 1,2,4-triazole derivatives as modulators of mglur5

Details Amino 1,2,4-triazole derivatives as modulators of mglur5 Amino 1,2,4-triazole derivatives as modulators of mglur5

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/439 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2702974

The present invention relates to new amino 1,2,4-triazole compounds, process for their preparation, pharmaceutical compositions containing said compounds an their use in therapy. The compounds act as modulators of metabotropic glutamate receptors (mG1uR) and thus useful in the treatment of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease, pain, anxiety and irritable bowel syndrome.

L'invention porte sur de nouveaux composés d'amino1,2,4-triazoles, sur leur procédé de préparation, sur des compositions pharmaceutiques contenant ces composés et sur leur utilisation thérapeutique. Lesdits composés agissent comme modulateurs des récepteurs métabotropiques du glutamate (mGluR) et sont par conséquent utilisés pour traiter le relâchement du sphincter inférieur de l'oesophage, le reflux gastro-oesophagien, la douleur, l'anxiété et le syndrome du côlon irritable.

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