C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2613435
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I. The present invention also provides methods for the use thereof to inhibit ~-secretase (BACE) and treat ~-amyloid deposits and neurofibrillary tangles
La présente invention décrit un dérivé de 2-amino-5-hétéroaryle-5-phénylimidazolone de formule I. La présente invention décrit également des méthodes d'emploi de ce dérivé dans l'inhibition de la .beta.-secrétase (BACE) et le traitement de dépôts de type .beta.-amyloïdes et d'enchevêtrements neurofibrillaires.
Li Yanfang
Malamas Michael Sotirios
Quagliato Dominick Anthony
Robichaud Albert Jean
Zhou Ping
Smart & Biggar
Wyeth
LandOfFree
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