Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimid...

Details Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimid... Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimid...

C - Chemistry, Metallurgy

07

D

C07D 233/88 (2006.01)

Patent

CA 2681243

The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

La présente invention concerne un composé 2-amino-5-[substitué-4-(difluorométhoxy)phényl]-5-phénylimidazolone de formule (I). La présente invention concerne également des procédés d'utilisation de celui-ci pour inhiber la b-sécrétase (BACE) et traiter des dépôts de b-amyloïde et des dégénérescences neurofibrillaires.

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