Amino acid amide for the production of sweetening agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

260/327, 260/363

C07D 333/36 (2006.01) C07D 331/04 (2006.01) C07C 103/50 (1980.01)

Patent

CA 1173450

ABSTRACT Disclosed herein is a compound of the formula Image (XXII) wherein Ra is methyl, ethyl, isopropyl or n-propyl and R is a member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butyl- carbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, cyclopropyl-t-butyl- carbinyl, cyclopentyl-t-butylcarbinyl, dicyclopropylcarbinyl, Image (Ia) where m1 is 1, 2 or 3 and when m1 is 1; R30, R40, R50 and R60 are each methyl, when m1 is 2; R30 is methyl, ethyl or isopropyl and R40, R50 and R60 are each hydrogen, or R30, and R50 are each methyl and R40 and R60 are each hydrogen, and when m1 is 3; (a) R30 is isopropyl or t-butyl and R40, R50 and R60 are each hydrogen, (b) R30 is ethyl, R50 is methyl and R40 and R60 are each hydrogen, or (c) R30 and R40 are each methyl and R50 and R60 are each hydrogen or methyl, and Image (Ib) wherein when n2 and p2 are each zero; R41 and R61 are each methyl and X2 is S, SO2, C=O or CHOH, when n2 is zero and p2 is 1; R41 and R61 are each methyl and X2 is O, S or SO2; and when n2 is 1 and p2 is 1; R41 and R61 are each hydrogen and X2 is S or SO2, which is useful as an intermediate for preparing a sweetening agent of the formula Image

440870

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