Amino acid amides of 5-amino-1,3,4-thiadiazones and their...

Details Amino acid amides of 5-amino-1,3,4-thiadiazones and their... Amino acid amides of 5-amino-1,3,4-thiadiazones and their...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07D 285/135 (2006.01) C07D 417/12 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224113

Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, are also disclosed.

L'invention concerne des amides aminoacides de 5-amino-1,3,4-thiadiazole-2-thione. Ces composés inhibent les métalloprotéinases matricielles et la dégradation du cartilage. Sont également décrits des procédés pour traiter des maladies provoquées par l'hyperactivité des métalloprotéinases matricielles, telles que l'arthrose et la polyarthrite rhumatoïde.

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