Amino acid compositions and use thereof in a clinical nutrition

Details Amino acid compositions and use thereof in a clinical nutrition Amino acid compositions and use thereof in a clinical nutrition

A - Human Necessities

61

K

A61K 31/195 (2006.01) A23L 1/29 (2006.01) A23L 1/30 (2006.01) A23L 1/305 (2006.01) A61K 31/198 (2006.01)

Patent

CA 2210499

The invention provides the use of at least one amino acid selected from the group consisting of glycine, alanine and serine, or the physiologically acceptable salts thereof, in the preparation of a medicament or nutritional formulation for the diminution of tumor necrosis factor (TNF) levels in patients in whom said levels are elevated beyond those which mediate physiological homeostasis and local inflammation. Such diminution of TNF levels can i.a. be achieved by inhibition or diminution of: (i) tumor necrosis factor (TNF) production by macrophage-type cells; (ii) the release of TNF from macrophage-type cells; and/or (iii) the binding of TNF by TNF receptors.

L'invention concerne l'utilisation d'au moins un acide aminé choisi dans le groupe constitué par glycine, alanine et sérine, ou des sels de ceux-ci acceptables sur le plan physiologique, dans la préparation d'une formulation médicamenteuse ou nutritionnelle destinée à diminuer les concentrations du facteur de nécrose tumorale (TNF) chez des patients chez lesquels ces concentrations sont supérieures à celles induisant l'homéostasie physiologique et l'inflammation locale. On peut obtenir une telle diminution des concentrations de TNF, entre autres, par inhibition ou diminution de: (i) la production du facteur de nécrose tumorale (TNF) par des cellules de type macrophage; (ii) la libération du TNF à partir des cellules de type macrophage, et/ou (iii) la fixation du TNF par des récepteur de celui-ci.

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