C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.06
C07K 5/06 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1275349
A B S T R A C T The invention relates to new carboxyalkyl dipeptide derivatives of the formula: Image wherein R is lower alkoxy; R1 is a substituted lower alkyl wherein the substituent is phenyl; R2 and R7 are hydrogen; R3 is lower alkyl; R4 is lower alkyl, R5 is lower alkyl; R4 and R5 may be connected together to form an alkylene bridge of from 2 to 4 carbon atoms; R6 is hydroxy; and the pharmaceutically acceptable salts thereof. These compounds are useful as converting enzyme inhibitors and as antihypertensives.
518334
Harris Elbert E.
Patchett Arthur A.
Tristram Edward W.
Wyvratt Matthew J.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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