Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2081236

RAN 4019/118 Abstract The compounds of the formula Image I wherein X, R1, R2, R3, R4 and R6 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured by reacting an aminodiol of the formula Image II with a corresponding acid or an activated derivative thereof.

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