Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

C - Chemistry, Metallurgy

07

C

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C07C 271/22 (2006.01) A61K 31/27 (2006.01) C07C 237/22 (2006.01) C07C 251/36 (2006.01) C07D 213/40 (2006.01) C07D 217/06 (2006.01) C07D 233/26 (2006.01) C07D 263/04 (2006.01) C07D 295/13 (2006.01) C07D 295/185 (2006.01) C07D 295/205 (2006.01) C07D 317/30 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2010531

RAN 4430/36 Abstract Compounds of the formula Image I wherein R1 represents alkoxycarbonyl, aralkoxy- carbonyl, alkanoyl, aralkanoyl, aroyl, cycloalkyl- carbonyl, heterocyclylcarbonyl, heterocyclyl-alkanoyl, 6-(dibenzylcarbamoyl)-4-oxohexanoyl or an acyl group of an .alpha.-amino acid in which the amino group is substituted by alkoxycarbonyl, aralkoxycarbonyl, diaralkylcarbamoyl, diaralkylalkanoyl or aralkanoyl: R2 represents alkyl, cycloalkylalkyl or aralkyl: R3 represents hydrogen or alkyl; R4 represents alkyl: and one of R5 and R6 represents hydrogen and the other represents hydrogen, alkyl, aryl, aralkyl, l-alkoxycarbonyl-2-phenylethyl, l-alkoxy- carbonyl-2-(imidazol-4-yl)ethyl, 2-(imidazol-1-yl)- ethyl, indanyl, heterocyclyl-alkyl, carboxyalkyl, alkoxycarbonylalkyl, aryloxycarbonylalkyl, aralkoxy- caebonylalkyl ne a group of the formula -A-N(Ra)(Rb) in which A represents alkylene and Ra and Rb each represent alkyl or Ra and Rb together represent a pentamethylene group in which one methylene group can be replaced by NH, N-alkyl, N-alkanoyl, N-aralkoxy- carbonyl, O, S, SO or SO2; or R5 and R6 together with the nitrogen atom to which they are attached represent a l,2,3,4-tetrahydcoisoquinoline ring: one of W and X represents hydrogen and the other represents hydroxy or amino or W and X together represent hydroxyimino and Y represents hydrogen or, where one of W and X represents hydroqen and the other represents hydroxy, Y can also represent hydroxy, and pharmaceutically acceptable acid addition salts thereof can be used as medicaments for the treatment and prophylaxis of viral infections, particularly of infections caused by HIV and other retroid viruses. They can be manufactured according to generally known procedures.

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