Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/47 (2006.01) C07C 237/22 (2006.01) C07C 237/24 (2006.01) C07C 255/29 (2006.01) C07C 323/60 (2006.01) C07D 213/81 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01) C07D 263/04 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2067690

Compounds of the formula (see formula I) wherein R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, heterocyclylcarbonyl or a group of the formula (see formula i) R2 represents alkyl, cycloalkylakyl or aralkyl; R3 represents hydrogen and R4 represents hydroxy or R3 and R4 together represent oxo; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted by alkyl or on adjacent carbon atoms by tetramethylene; R8 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aroyl, aralkanoyl or heterocyclylcarbonyl; and R9 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, cyanoalkyl, carbamoyl- alkyl, alkylthioalkyl, alkoxyalkyl or alkoxycarbonylalkyl, and pharmaceutically acceptable acid addition salts of those compounds of formula I which are basic, inhibit aspartyl proteases of viral origin and can be used in the form of medica- ments for the prophylaxis or treatment of viral infections. They can be manufactured according to generally known methods.

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