C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 260/304
C07D 233/90 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2023099
RAN 4019/109 Abstract The compounds of the formula Image I wherein A, R1, R2, R3, R4, R5, R6, R7 and R8 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.
Branca Quirico
Neidhart Werner
Ramuz Henri
Stadler Heinz
Wostl Wolfgang
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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