Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

C - Chemistry, Metallurgy

07

K

167/208, 260/285

C07K 5/072 (2006.01) A61K 31/40 (2006.01) A61K 38/05 (2006.01) C07D 207/16 (2006.01) C07D 209/42 (2006.01) C07D 209/52 (2006.01) C07D 211/60 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 277/06 (2006.01) C07D 279/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01) C07K 5/02 (2006.01)

Patent

CA 1340588

Compounds of the formula (see fig. I) wherein R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or .alpha.-aralkoxycarbonyl- aminoalkanoyl and R2 represents hydrogen or R1 and R2 together with the nitrogen atom to which they are attached represent a cyclic imide group of the formula (see fig. II) in which P and Q together represent an aromatic system; R3 represents alkyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl, cyanoalkyl, alkyl- sulphinylalkyl, carbamoylalkyl or alkoxycarbonylalkyl or, when n stands for zero, R3 can also represent alkylthioalkyl or, when n stands for 1, R3 can also represent alkylsulphonylalkyl; R4 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; R5 represents hydrogen and R6 represents hydroxy or R5 and R6 together represent oxo; R7 and R8 together represent a trimethylene or tetramethylene group which is optionally substituted by hydroxy, alkoxycarbonylamino or acylamino or in which one -CH2- group is replaced by -NH-, -N(alkoxycar- bonyl)-, -N(acyl)- or -S- or which carries a fused cycloalkane, aromatic or heteroaromatic ring; and R9 represents alkoxycarbonyl, monoalkylcarbamoyl, monoaralkylcarbamoyl, monoarylcarbamoyl or a group of the formula (see fig. III) in which R10 and R11 each represent alkyl; and their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment or prophylaxis of viral infections. They can be manufactured according to generally known procedures.

601434

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