C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/065 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2051455
ABSTRACT Compound of the formula: Image wherein R1 is morpholinocarbonyl, thiomorpholinocarbonyl, hexahydro-1H-azepin-1-ylcarbonyl, octahydroazocin-1-ylcarbonyl, piperidinocarbonyl, lower alkanoyl, dipropylcarbamoyl, tetrahydroisoquinolylcarbonyl or a heterocyclic group, R2 is lower alkyl, R3 is lower alkyl which may be substituted with substituent(s) selected from the group consisting of aryl and cyclo(lower)alkyl, R4 is lower alkyl, X is lower alkylene, Y1 is a single bond or Image , in which R5 is lower alkyl, and Y2 is -NH- or -O-, provided that R3 is isobutyl, 2-ethylbutyl or lower alkyl substituted with substituent(s) selected from the group consisting of aryl and cyclo(lower)alkyl, 1) when R1 is morpholinocarbonyl and Y1 iS Image ; 2) when R1 is morpholinocarbonyl or thiomorpholinocarbonyl, Y1 is a single bond and Y2 is -O-; or 3) when R1 is lower alkanoyl and Y2 is -O-; and their pharmaceutically acceptable salts. The preparation of these compounds, pharmaceutical compositions containing them and their uses for therapeutic treatment and the pre- vention of hypertension, heart failure, renal diseases or glaucoma in humans and animals, are also disclosed.
Hashimoto Masashi
Hemmi Keiji
Marusawa Hiroshi
Neya Masahiro
Watanabe Shinya
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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