C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
530/7.04, 260/46
C12P 21/00 (2006.01) A61K 8/44 (2006.01) A61K 8/64 (2006.01) A61K 8/98 (2006.01) A61K 31/195 (2006.01) A61K 35/55 (2006.01) A61Q 11/00 (2006.01) A61Q 17/00 (2006.01) A61Q 19/00 (2006.01) C07F 9/08 (2006.01) C07F 9/09 (2006.01) C07K 14/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1051802
ABSTRACT OF THE DISCLOSURE Novel compounds of the general formula (I), Image (I) and their salts and optically active isomers have been pre- pared. The new compounds according to the invention possess valuable pharmacological and therapeutical properties. In the above formula A1 stands for hydroxy, C1-4 alkoxy, cycloalkoxy, aralkoxy, substituted aralkoxy, aryloxy, substituted aryloxy or a group of the general formula -NR?4 or Image wherein R14 is hydrogen, C1-4 alkyl or aralkyl, R6 is hydrogen, C1-5 alkyl, aralkyl, hydroxyl-substituted aralkyl, heteroaralkyl or a group of the general formula Image Y is hydroxy, amino, alkylamino, dialkylamino, C1-4 alk- oxy or aralkoxy, and r is an integer of from 1 to 10 or an average polymeriza- tion grade of up to 2000, B1 is a group of the formula -SO2OH, -OSO2OH, -O-PO(OH)2 or -S-S-R-11, wherein R11 is C1-4 alkyl, aralkyl or aryl or a residue obtained when removing group B1 from the general formula (I), R stands for hydrogen, C1-4 alkyl or aralkyl, R? stands for hydrogen or halogen, R1 stands for hydrogen C1-4 alkyl, aryl, aryl having a nitro or alkoxy substituent, aralkyl, substituted aralkyl, alkoxycarbonyl, aralkoxycarbonyl, aralkoxycarbonyl having a halogen, alkoxy, nitro, phenylaso, or alkoxyphenylaso substituent, alkyl-substituted aryloxycarbonyl, acyl, benzoyl, arylsulfonyl or -(NH-??-CO)p group (wherein R6 has the same meanings as defined above and p is an integer of from 1 to 10 or an average polymerization grade of up to 2000), or a -CO- group, R2 stands for hydrogen, C1-4 alkyl, aralkyl or a -CO- group, but if R1 and R2 each stand for a -CO- group, they form a ring through an o-phenylene, alkylene or -CH=CH- group, R3 stands for hydrogen, carboxy or carbalkoxy, R4 stands for hydrogen, halogen C1-4 alkyl or hydroxy, R5 stands for hydrogen, halogen, C1-4 alkyl, carboxy, carbox- amino, carbalkoxy or carboaralkoxy, n is 1, 2 or 3, n is 1, 2, or 4, s is 0, 1, 2, 3 or 4, and t is 1, 2 or 3.
225659
Bendefy Erzsebet
Feuer Laszlo
Furka Arpad
Hercsel Jolan
Sebestyen Ferenc
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt.
Na
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