Amino acid derivatives as calcium channel blockers

Details Amino acid derivatives as calcium channel blockers Amino acid derivatives as calcium channel blockers

A - Human Necessities

61

K

A61K 31/166 (2006.01) A61K 31/277 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2688267

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both an amino acid functionality and multiple aromatic rings are disclosed of the general formula (1) where X is benzhydryl, or an aromatic or heteroaromatic ring.

L'invention concerne des procédés et des composés efficaces pour améliorer des conditions caractérisées par une activité des canaux calciques non souhaitée, en particulier une activité des canaux calciques de type N et/ou de type T non souhaitée. Spécifiquement, l'invention concerne une série de composés contenant à la fois une fonctionnalité d'acide aminé et de multiples cycles aromatiques de la formule générale (I) dans laquelle X est benzhydryle, ou un cycle aromatique ou hétéro-aromatique.

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