Amino acid derivatives as paf-receptor antagonists

Details Amino acid derivatives as paf-receptor antagonists Amino acid derivatives as paf-receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07C 233/47 (2006.01) C07C 309/63 (2006.01) C07D 213/56 (2006.01) C07D 213/57 (2006.01) C07D 235/08 (2006.01) C07D 401/02 (2006.01) C07D 405/02 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2127365

2127365 9314072 PCTABS00024 Compounds of general formula (I), wherein W represents pyrid-3-yl, benzimidazol-1-yl, imidazo(4,5-c)pyridin-1-yl, imidazo(4,5-c)pyridin-3-yl and imidazo(4,5-c)pyridin-5-yl optionally substituted by alkyl; Z represents: a) a divalent alkanediyl, alkenediyl or alkynediyl group, b) a -(CH2)qU(CH2)r- group, optionally substituted, q is an integer from 0-3, r is an integer from 0-3 and U is -O-, -S- or a furandiyl, tetrahydrofurandiyl, thiophenediyl, tetrahydrothiophenediyl, thiazolediyl, tetrahydrothiazolediyl, piperazinediyl, piperidinediyl, cyclopentanediyl, cyclohexanediyl, cycloheptenediyl or benzenediyl group; or c) a (.alpha.) group wherein m is an integer from 0-3, X is -O-, -S- or -CH2- and each of R4 and R5 is independently hydrogen or alkyl; Q represents a carbonyl, thiocarbonyl or sulphonyl group or a bond; B represents: a) a -VR8 group wherein V is -C(=O)-, -C(=O)O-, -CH2O-, -CH2OC(=O)-, -C(=S)-, -CH2OC(=O)NH-, -C(=S)O-, -CH2S-, -C(=O)NHSO2- or -SO2NHC(=O)-; b) a -CH2NR9R10 group or a -CONR9R10 group; c) a group Y where Y is a 5- or 6-membered heterocyclic ring; d) a group -CH2-Y or C(=O)NHY; are antagonists of platelet activating factor (PAF).

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