Amino acid derivatives inhibiting extracellular matrix...

Details Amino acid derivatives inhibiting extracellular matrix... Amino acid derivatives inhibiting extracellular matrix...

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) C07C 323/41 (2006.01) C07D 209/20 (2006.01) C07D 209/26 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2287565

The invention concerns compounds of general formula (X) in which Y represents in particular -CONHOH, R1 represents in particular a C3-C16 linear or branched or C3-C6 cyclized alkyl chain, R2 represents in particular a C1-C5 alkyl group, AA represents an amino acid, or an amino acid sequence, and R3 represents in particular a group of formula -NH -(CH2)2-SCH3. The invention also concerns the pharmaceutical compositions containing them, and the methods for obtaining them.

L'invention a pour objet les composés de formule générale (X) dans laquelle Y représente notamment -CONHOH, R1 représente notamment une chaine alkyle linéaire ou ramifiée en C3 à C16, ou cyclisée en C3 à C6, R2 représente notamment un groupe alkyle de 1 à 5 atomes de carbone, AA représente un acide aminé, ou un enchaînement d'acides aminés, et R3 représente notamment un groupe de formule -NH-(CH2)2-SCH3, les compositions pharmaceutiques les contenant, ainsi que leurs procédés d'obtention.

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