Amino acid derivatives, pharmaceutical compositions...

Details Amino acid derivatives, pharmaceutical compositions... Amino acid derivatives, pharmaceutical compositions...

C - Chemistry, Metallurgy

07

C

C07C 279/14 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07C 257/14 (2006.01) C07C 257/18 (2006.01) C07C 275/20 (2006.01) C07C 275/24 (2006.01) C07C 275/56 (2006.01) C07C 279/24 (2006.01) C07C 279/36 (2006.01) C07C 307/06 (2006.01) C07C 311/35 (2006.01) C07C 311/46 (2006.01) C07D 209/08 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 209/24 (2006.01) C07D 209/42

Patent

CA 2238859

The invention relates to new amino acid derivatives of general formula (I), wherein B, T, Z, Y, V and n are defined as in claim 1, the tautomers, diastereomers and enantiomers thereof, the mixtures thereof and the salts thereof, particularly their physiologically acceptable salts with inorganic or organic acids or bases which have valuable pharmacological properties, particularly selective NPY-antagonist properties, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.

L'invention concerne des nouveaux dérivés d'acides aminés de la formule générale (I), dans laquelle B, T, Z, Y, V et n sont tels que définis dans la revendication 1. L'invention concerne également des tautomères, diastéréomères et énantiomères de ces dérivés et leurs mélanges, ainsi que des sels de ces dérivés, notamment des sels d'addition d'acides ou de bases inorganiques ou organiques, acceptables sur le plan physiologique. Ces dérivés possèdent des propriétés pharmacologiques précieuses, notamment des propriétés antagonistes du neuropeptide Y. On décrit encore des compositions pharmaceutiques contenant ces composés ainsi que l'utilisation et des procédés de préparation de celles-ci.

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