Amino acid derivatives used as pharmaceutical substances

Details Amino acid derivatives used as pharmaceutical substances Amino acid derivatives used as pharmaceutical substances

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 31/401 (2006.01) A61P 7/02 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2713780

The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing said pharmaceutical substances to permeate the blood-brain barrier, said pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing correspondingly modified pharmaceutical substances.

L'invention concerne un procédé pour améliorer la biodisponibilité de substances pharmaceutiques et pour permettre à ces dernières de franchir la barrière hémato-encéphalique, lesdites substances pharmaceutiques présentant au moins une ou plusieurs fonctions amidine, guanidine, N-hydroxyamidine (amidoxime) ou N-hydroxyguanidine. L'invention concerne également des médicaments contenant des substances pharmaceutiques modifiées de manière correspondante.

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