Amino acid derived prodrugs of propofol, compositions and...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 31/05 (2006.01) A61P 25/00 (2006.01) C07C 39/07 (2006.01) C07C 55/12 (2006.01) C07C 55/14 (2006.01)

Patent

CA 2510677

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post- chemotherapy or post-operative surgery nausea and vomiting.

L'invention concerne des promédicaments de propofol, des procédés de fabrication desdits promédicaments, des compositions pharmaceutiques contenant des promédicaments de propofol et des procédés d'utilisation desdits promédicaments et des compositions pharmaceutiques, permettant le traitement ou la prévention des maladies ou des troubles tels que des migraines, et les nausées et vomissements post-chimiothérapeutiques ou postopératoires.

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