Amino acid, ester and/or catechol contrast agents for mri

Details Amino acid, ester and/or catechol contrast agents for mri Amino acid, ester and/or catechol contrast agents for mri

C - Chemistry, Metallurgy

07

F

C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) C07C 229/16 (2006.01) C07C 237/12 (2006.01) C07D 209/20 (2006.01) C07F 11/00 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2115275

2115275 9303351 PCTABS00019 The present invention relates to the preparation of amino acid containing compounds which also have multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono and di-amino acids (and their carboxylic esters carboxylic amides, and catechols) of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.

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