Amino acid ester containing azole antifungals

Details Amino acid ester containing azole antifungals Amino acid ester containing azole antifungals

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/496 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2262791

The present invention concerns novel compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein -A-B- forms a bivalent radical of formula -N-CH- (a), -CH=N- (b), -CH=CH- (c), L represents the acyl moiety of an amino acid; D is an azole containing 1,3- or 1,4-dioxolane derivative as broad-spectrum antifungals; their preparation, compositions containing them and their use as a medicine.

Cette invention concerne de nouveaux composés de formule (I) leurs formes N-oxyde, leurs seuls d'addition pharmaceutiquement acceptables et leurs formes stéréochimiquement isomères. Dans la formula (I) -A-B- forme un radical divalent de formule -N=CH-(a), -CH=N (b), -CH=CH- (c), L représente la fraction acyle d'un acide aminé; D représente un azole contenant un dérivé de 1,3 ou 1,4-dioxolane en tant qu'antifongique à large spectre; on décrit leur préparation, des compositions contenant ces composés et leur utilisation comme médicament.

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