Amino acid ester prodrugs and the use thereof

Details Amino acid ester prodrugs and the use thereof Amino acid ester prodrugs and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2746727

The present application relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4--chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3- dihydroxypropyl]oxy}phenyl)pyridine--3,5-dicarbonitriles, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

La présente invention concerne des dérivés promédicamenteux d'esters d'acides aminés, à savoir des dérivés promédicamenteux de 2-amino-6-([2-(4-chlorphényl)-1,3-oxazol-4-yl]méthylsulfanyl)4-(4-[2,3-dihydroxypropyl]oxyphényl)pyridin-3,5-dicarbonitrile de la formule (I) dans laquelle RA représente de l'hydrogène ou du méthyle et R PD un groupe de la formule (II) ou (III) où # représente le point de liaison avec l'atome O, son procédé de production, son utilisation pour le traitement et/ou la prophylaxie de maladies ainsi que son utilisation pour la fabrication de médicaments pour le traitement et/ou la prophylaxie de maladies, notamment de maladies cardiovasculaires.

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