Amino acid hydroxyethylamino sulfonamide retroviral protease...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07D 307/79 (2006.01) C07D 311/58 (2006.01) C07D 317/62 (2006.01) C07D 319/18 (2006.01) C07D 339/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2215061

Selected amino acid hydroxyethylamino sulfonamide compounds of formula (I) are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

L'invention porte sur des composés sélectionnés du type hydroxyéthylamino sulfonamide à aminoacide de formule (I) s'avérant efficaces comme inhibiteurs de protéases rétrovirales et notamment de celle du VIH et plus particulièrement sur de nouveaux composés, compositions et procédés d'inhibition des protéases rétrovirales telle que celle du VIH, de prévention prophylactique et de traitement des infections rétrovirales, et de prévention de la dissémination des rétrovirus.

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