Amino acid inhibitors of cytochrome p450

Details Amino acid inhibitors of cytochrome p450 Amino acid inhibitors of cytochrome p450

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/343 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61P 31/14 (2006.01) C07D 307/79 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2716347

Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Linvention concerne des méthodes d'inhibition des enzymes du cytochrome P450, qui peuvent être utilisées pour améliorer le traitement de maladies en empêchant la dégradation de médicaments ou autres molécules par le cytochrome P450. Des compositions pharmaceutiques sont mises en uvre, qui peuvent agir comme renforçateurs de la pharmacocinétique, améliorer la biodisponibilité et accentuer l'effet thérapeutique de médicaments subissant une dégradation in vivo provoquée par les enzymes du cytochrome P450.

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