C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/06 (2006.01) A61K 38/23 (2006.01) A61K 39/21 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/585 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2453809
The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.
Bohling James Charles
Kinzey Marlin Kenneth
Maikner John Joseph
Ziarno Witold Andrew
Gowling Lafleur Henderson Llp
Rohm And Haas Company
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