Amino acid modified polypeptides

Details Amino acid modified polypeptides Amino acid modified polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/78 (2006.01) C12N 15/67 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2639620

Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.

Affiliated with

Also associated with

Rating

Amino acid modified polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino acid modified polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino acid modified polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1420914